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WASHINGTON (AP) — President Joe Biden says most Americans are "frustrated" by 80 million of their neighbors who remain unvaccinated, and says they are hurting the nation as he announces new mandates.

Biden is announcing sweeping new federal vaccine requirements affecting as many as 100 million Americans in an all-out effort to increase COVID-19 vaccinations and curb the surging delta variant that is killing thousands each week and jeopardizing the nation’s economic recovery.

RELATED: Biden to announce new vaccine mandates that could cover 100 million Americans

The expansive rules mandate that all employers with more than 100 workers require them to be vaccinated or test for the virus weekly, affecting about 80 million Americans. And the roughly 17 million workers at health facilities that receive federal Medicare or Medicaid also will have to be fully vaccinated.

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President Joe Biden has announced new vaccination requirements for employers. Visit whitehouse.gov/covidplan to read through the plan in full.  

Biden is also signing an executive order to require vaccination for employees of the executive branch and contractors who do business with the federal government — with no option to test out. That covers several million more workers.

Biden announced the new requirements in a Thursday afternoon address from the White House as part of a new “action plan” to address the latest rise in coronavirus cases and the stagnating pace of COVID-19 shots that has raised doubts among the public over his handling of the pandemic.

Click here to view that action plan in full